Human Metapneumovirus Infection Plays an Etiologic Role in Acute Asthma Exacerbations Requiring Hospitalization in Adults.

Autor: Williams, John V., Crowe, Jr., James E., Enriquez, Rachel, Minton, Patricia, Peebles, Jr., R. Stokes, Hamilton, Robert G., Higgins, Stanley, Griffin, Marie, Hartert, Tina V.
Předmět:
Zdroj: Journal of Infectious Diseases; 10/1/2005, Vol. 192 Issue 7, p1149-1153, 5p
Abstrakt: We determined the prevalence of human metapneumovirus (hMPV) infection in adults with asthma who were prospectively enrolled after hospitalization for an acute asthma exacerbation. Nasal wash specimens collected at admission and 3 months after discharge were tested for hMPV by real-time reverse-transcription polymerase chain reaction assays. hMPV was detected in 7 (6.9%) of 101 subjects at hospitalization and in 1 (1.3%) of 75 subjects at follow-up (odds ratio, 7 [95% confidence interval, 0.9-312]; P = .03 ). None of the patients with hMPV infection at hospitalization tested positive at follow-up, strongly suggesting that hMPV plays a direct etiologic role in acute asthma exacerbations. [ABSTRACT FROM AUTHOR]
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