| Autor: |
Ohmann, Christian, Imhof, Michael, Ruppert, Christian, Janzik, Ulf, Vogt, Christoph, Frieling, Thomas, Becker, Klaus, Neumann, Frank, Faust, Stephan, Heiler, Klaus, Haas, Klaus, Jurisch, Rainer, Wenzel, Ernst-Günter, Normann, Stefan, Bachmann, Oliver, Delgadillo, Jorge, Seidel, Florian, Franke, Claus, Lüthen, Reinhard, Yang, Qin |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Gastroenterology; Aug2005, Vol. 40 Issue 8, p914-920, 7p, 5 Charts |
| Abstrakt: |
Objective. Despite the introduction of effective medical treatment of peptic ulcer disease, bleeding is still a frequent complication. The aim of this study was to investigate whether the incidence and the risk profile of peptic ulcer haemorrhage have changed within a 10-year period. Material and methods. In a prospective epidemiological and observational study the incidence and risk profile of peptic ulcer haemorrhage in Dusseldorf, Germany were compared between two time periods (period A: 1.3.89-28.2.90 and period B: 1.4.99-31.3.2000), involving nine hospitals with both surgical and medical departments. Patients with proven peptic ulcer haemorrhage at endoscopy or operation were included in the study; those with bleeding under defined severe stress conditions were excluded. Results. No differences in bleeding ulcer incidence were observed between periods A and B (51.4 per 100,000 person-years versus 48.7), or for duodenal ulcer (24.9 versus 25.7) or for gastric ulcer bleeding (26.5 versus 23.0). A marked increase in incidence rates was observed with increasing age. In period B, patients with bleeding ulcers were older (56% versus 41% 70 years or older), were usually taking non-steroidal anti-inflammatory drugs (NSAIDs) (45% versus 27%) and were less likely to have a history of ulcer (25% versus 59%) compared with patients in period A. Conclusions. The persisting high incidence of peptic ulcer disease is a superimposing of two trends: a higher incidence in the growing population of elderly patient with a higher intake of NSAIDs and a lower incidence among younger patients due to a decrease in incidence and improved medical treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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