| Autor: |
Eldad J. Dann, Ron Epelbaum, Irit Avivi, Menachem Ben Shahar, Nissim Haim, Jacob M. Rowe, Zeev Blumenfeld |
| Předmět: |
|
| Zdroj: |
Human Reproduction; Aug2005, Vol. 20 Issue 8, p2247-2249, 3p |
| Abstrakt: |
BACKGROUND: Intensive chemotherapy is widely used to improve the outcome of aggressive non-Hodgkin lymphoma (NHL). Since these regimens may cause premature ovarian failure (POF), the ovarian function was studied in 13 consecutive women aged =40 years, treated with four cycles of intensified CHOP (cyclophosphamide 20003000?mg/m2 per cycle doxorubicin 50?mg/m2, vincristine 1.4?mg/m2 (maximum 2?mg) and prednisone 100?mg/day were given every 3 weeks). METHODS: Patients aged <60 years with aggressive NHL were eligible for participating in a non-randomized phase II study if they had stage I, II, B, bulky, or stages III, IV disease with the age-adjusted international prognostic index of lowintermediate to high-risk score. Seven patients were concomitantly treated with d-TRP6-GnRH analogue (Decapeptyl; Ferring, Germany) for minimizing gonadal toxicity. RESULTS: With a median follow-up of 70 months only one patient had POF, while 12 patients retained fertility and eight conceived spontaneously delivering 12 healthy babies. CONCLUSION: It appears that high-dose cyclophosphamide does not affect the ovarian function or fertility in patients exposed to this medication during four consecutive cycles of intensified CHOP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
