Findings from Meizhou People's Hospital in Parkinson's Disease Reported [Gsk-3(3 Inhibitor Amplifies Autophagy-lysosomal Pathways By Regulating Tfeb In Parkinson's Disease Models].

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Zdroj: Drug Week; 1/10/2025, p828-828, 1p
Abstrakt: Researchers at Meizhou People's Hospital in China have conducted a study on Parkinson's Disease, focusing on the role of GSK-3(3 inhibitors in alleviating mitochondrial damage and neuronal cell loss. The study found that inhibiting GSK-3(3 activity promoted the nuclear translocation of TFEB, amplifying the autophagy-lysosomal pathway and improving motor function in mouse models of PD. This research suggests that targeting GSK-3(3 activity could be a potential therapeutic approach for delaying the progression of Parkinson's Disease. [Extracted from the article]
Databáze: Complementary Index