| Autor: |
Dian, Sofiati, Ardiansyah, Edwin, Chaidir, Lidya, Laarhoven, Arjan van, Ruslami, Rovina, Alisjahbana, Bachti, Ganiem, Ahmad Rizal, Crevel, Reinout van |
| Zdroj: |
Open Forum Infectious Diseases; Dec2024, Vol. 11 Issue 12, p1-8, 8p |
| Abstrakt: |
Background Hyponatremia is common in tuberculous meningitis (TBM), but its impact on disease severity and outcomes is unclear. Methods In a cohort of 864 adult patients with TBM in Indonesia, we assessed the prevalence and prognostic significance of hyponatremia, classified as moderate (120–130 mEq/L) or severe (<120 mEq/L). Patients received standard antituberculous therapy and corticosteroids and were followed for 1-year mortality. Results Hyponatremia occured in 86.8% of patients, with 26% classified as severe. Severe hyponatremia associated with male, younger age, a lower Glasgow Coma Scale (GCS), and markers of more severe disease (P <.05). One-year mortality was 46.5% and associated with older age, HIV infection, lower GCS, markers of neurologic severity, fever, and thrombocytosis. Severe hyponatremia predicted mortality in univariate analysis showed no impact in HIV-positive patients. Conclusions Hyponatremia reflects disease severity in TBM but does not independently predict mortality, suggesting limited benefit from agressive correction. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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