Unlocking the Puzzle: Investigating the Role of Interleukin 17 Genetic Polymorphisms, Circulating Lymphocytes, and Serum Levels in Venezuelan Women with Recurrent Pregnancy Loss.

Autor: Garmendia, Jenny Valentina, Blanca, Isaac, Peña, María Johanna, De Sanctis, Claudia Valentina, De Sanctis, Juan Bautista
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Zdroj: Immuno; Dec2024, Vol. 4 Issue 4, p301-311, 11p
Abstrakt: In recurrent pregnancy loss (RPL), peripheral and local immune cells are activated, decreasing the leukocyte tolerogenic response in the uterus and decidua. The aim was to examine the role of IL-17 in RPL critically. The study included genetic polymorphism, the analysis of the number of circulating IL-17 lymphocyte populations, before and after cell priming, serum cytokine quantification, and the assessment of T-reg cells in a group of 50 RPL and 50 normal women from the admixed Venezuelan population. The study found no differences in the genetic polymorphisms rs2275913 and rs763780. However, when IL-17+ cell populations of controls and RPL patients were compared, a significant increase was observed in the cell populations CD3+ and CD4+ (p < 0.001), while the contrary was recorded in CD8+ and CD56+ cells. Upon cell priming, all IL-17+ populations were significantly decreased (p < 0.001) in RPL patients compared to controls. The increase in IL-17A in the serum of RPL patients may be due to the CD4+ population, while cell exhaustion after activation could be responsible for decreased CD8+ cell population. The number of CD4CD25 FoxP3+ cells was significantly reduced (p < 0.001), and the number of activated HLADR+ cells was significantly increased (p < 0.001) in RPL patients. The absence of differences in the genetic polymorphism compared to controls suggests that biological factors influence IL-17 levels in RPL patients. This finding has significant implications for the understanding and potential treatment of RPL. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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