| Autor: |
Gopichand Thakur, Dinesh, Sonawane, Mahesh A., Patel, Raj N., Rathod, Nileshkumar B., Patel, Sachinkumar D., Patel, Dharmik M., Chandra Ghosh, Subhash |
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| Zdroj: |
Advanced Synthesis & Catalysis; 12/17/2024, Vol. 366 Issue 24, p4994-5000, 7p |
| Abstrakt: |
This article describes the development of a room‐temperature visible‐light‐induced palladium‐catalyzed directed aldehyde C−H bond arylation to access aryl quinolinyl ketones. In this pathway, the Pd catalyst plays a dual role by harvesting light as a photocatalyst and catalyzing the chemical transformation via C−H bond activation. This process is general to synthesize a range of aryl quinolinyl ketones and tolerates many common functional groups. Our methodology was successfully applied to synthesize highly potent tubulin polymerization inhibitors. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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