| Autor: |
Liu, Fang, Li, Chunmei, Di, Man, Shu, Boqi, Xiao, Xifeng |
| Zdroj: |
Expert Review of Molecular Diagnostics; Dec2024, Vol. 24 Issue 12, p1151-1158, 8p |
| Abstrakt: |
Background: This study aimed to validate HNF1B single nucleotide polymorphisms (SNPs) associated with endometrial cancer risk in a Chinese Han population and explore novel SNPs. Our findings enhance the understanding of genetic components and are crucial for detection strategies and personalized medicine. Methods: We genotyped four HNF1B SNPs in 637 patients and 667 controls using Agena MassARRAY. Logistic regression calculated odds ratios (ORs) and 95% CI. Forest plots visualize stratified analyses. Multiple comparisons tested genetic loci-clinical indicator associations. Results: The study confirmed that rs4430796 (A>G) reduced endometrial cancer risk (OR = 0.83, 95% CI: 0.70–0.99, p = 0.041). Additionally, novel HNF1B mutations were associated with endometrial cancer risk: rs7405776 in individuals under the age of 55 (OR = 047, 95% CI: 0.25–0.91, p = 0.025) and nonsmokers (OR = 0.42, 95% CI: 0.23–0.75, p = 0.004), and rs11651755 in drinkers (OR = 0.39, 95% CI: 0.17–0.90, p = 0.027) and nonsmokers (OR = 0.43, 95% CI: 0.23–0.81, p = 0.009). The SNP rs4430796 was also associated with the CA125 level (p < 0.05). Conclusion: HNF1B polymorphisms influence endometrial cancer risk in the Chinese Han population. Further studies are needed to explore the functional roles and clinical practicality of these SNPs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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