| Autor: |
Hendawy, Amira Ayman, Elgharbawy, Amal A. M., Mohd Noor, Najihah, Al-Saari, Nurhidayu, Azmi, Nor Azrini Nadiha, Mohd Salleh, Hamzah |
| Předmět: |
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| Zdroj: |
Colloids & Interfaces; Dec2024, Vol. 8 Issue 6, p59, 15p |
| Abstrakt: |
Nanoemulsions, characterized by their nanosized particles ranging from 20 to 200 nm, are effective carriers for drug molecules. Our novel oil-in-water nanoemulsion, NE-FLO™, formulated from lemon and fish byproduct oils, demonstrates promising antioxidant and anti-inflammatory activities, with initial studies indicating nontoxicity to normal skin cells. This study investigated the safety of NE-FLO™ using brine shrimp (Artemia salina) and zebrafish (Danio rerio) models, focusing on concentration-dependent effects and LC50 values. At lower concentrations (0.1 mg·L−1, 0.01 mg·L−1, and 0.001 mg·L−1), NE-FLO™ showed minimal toxicity without adverse effects. However, at 1 mg·L−1, reduced survival rates indicate potential toxicity. Specifically, this concentration also induces altered swimming behaviors in zebrafish. LC50 values are 8.7474 mg·L−1 for brine shrimp and 0.316 mg·L−1 for adult zebrafish. These results underscore the necessity for further detailed investigations into NE-FLO™, balancing its therapeutic benefits with potential toxicity risks. This study emphasizes the importance of optimizing nanoemulsion formulations from fish oil and conducting comprehensive safety assessments to meet regulatory standards. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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