Associations of Lipid Metabolites with Insulin Resistance and Hypertriglyceridemia in Youth.

Autor: Liu, Xiaoxiao, Ma, Shifeng, Li, Jing, Song, Mingkun, Li, Yun, Fang, Zhongze, Zheng, Rongxiu
Předmět:
Zdroj: Clinical & Translational Metabolism; 12/28/2024, Vol. 22 Issue 1, p1-11, 11p
Abstrakt: This study is aimed at exploring the associations of lipid metabolites with insulin resistance (IR) and hypertriglyceridemia among children and adolescents. We recruited 630 young individuals aged 4 to 17 years and divided them into two groups: low-IR and high-IR. MS metabolomic analysis was used to measure 75 lipid metabolites in plasma. IR-specific lipid metabolites are illustrated via volcano plot. We used regression models to evaluate the relationships between IR-specific lipid metabolites and IR and hypertriglyceridemia. Furthermore, we applied bootstrapping to test the mediating effect of triglyceride (TG) on the relationship between IR-specific lipid metabolites and IR. In our study, there were 379 individuals in the low-IR group and 251 individuals in the high-IR group. We identified 9 children-specific IR-associated lipid metabolites, of which 16:0–18:1 PE, 18:0–18:2 PE, and 18:0 PE were positively associated with the risk of IR (OR = 1.909, 95% CI = 1.084–3.361, p = 0.025; OR = 1.890, 95% CI = 1.065–3.355, p = 0.030; respectively). Additionally, correlation heat maps revealed associations between TG and 16:0–18:1 PE, 26:0 Lyso PC, and 22:1 (Cis) PC. Further multivariate binary logistics regression analysis revealed that 16:0–18:1 PE was significantly associated with hypertriglyceridemia (OR = 1.949, 95% CI = 1.212–3.133, p = 0.006). TG plays a partial mediating role in the relationship between 16:0–18:1 PE and HOMA-IR, with the proportion of the mediation effect relative to the total effect being 18.29% (95% CI of the mediating effect for TG was 0.004–0.082). Increased levels of 16:0–18:1 PE, 18:0–18:2 PE, and 18:0 PE are associated with increased risks of IR. Increased levels of 16:0–18:1 PE are associated with increased risks of hypertriglyceridemia. TG may mediate the impact of IR driven by 16:0–18:1 PE. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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