| Autor: |
Martinez, Caitlin E., Nezami, Brooke T., Mayer‐Davis, Elizabeth, Willis, Erik A., Gorin, Amy A., Tate, Deborah F. |
| Předmět: |
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| Zdroj: |
Obesity Science & Practice; Dec2024, Vol. 10 Issue 6, p1-13, 13p |
| Abstrakt: |
Objective: Adaptive interventions may improve the potency and scalability of behavioral weight loss interventions, but the treatments—or treatment combinations—that should be offered are unknown. A two‐stage pilot sequential multiple assignment randomized trial was used to test the timing and dose of human support added to a core digital weight loss program. Methods: In stage 1, 99 adults with overweight/obesity were randomized at baseline to a kick‐off with or without additional human support. In stage 2, "early non‐responders" who had not achieved a 2% weight loss were re‐randomized after 4 weeks to either biweekly counseling (120 min over 8 weeks) or a one‐time check‐in (30 min) with a dietitian. "Early responders" continued with the mHealth program alone. Feasibility and acceptability were assessed against pre‐specified criteria. Preliminary outcomes (weight loss, self‐monitoring and behavioral goal adherence) were explored. Results: The study met all feasibility and acceptability criteria. The rate of early response was 52.5%. Mean (SE) 3‐month percent weight losses were significantly greater in early responders (−6.63% (0.72)) than non‐responders (−1.70% (0.43), p < 0.001). Outcomes were similar by first‐ and second‐line treatment though more counseling (27.3%) than check‐in (12.5%) participants achieved a 5% weight loss. Conclusions: Identifying early responders may help optimize weight loss interventions, but more research is needed on rescue treatments for early non‐responders. Trial Registration: ClinicalTrial.gov, NCT05929469. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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