| Autor: |
de Camargo, Laura Junqueira, Alves, Raquel Silva, dos Santos, Raíssa Nunes, Baumbach, Letícia Ferreira, Olegário, Juliana do Canto, Rabaioli, Vitória, Silva, Matheus de Oliveira, Witt, André Alberto, Godinho, Fernanda Marques, Salvato, Richard Steiner, Weber, Matheus Nunes, da Silva, Mariana Soares, Daudt, Cíntia, Budaszewski, Renata da Fontoura, Canal, Cláudio Wageck |
| Předmět: |
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| Zdroj: |
Animals (2076-2615); Dec2024, Vol. 14 Issue 24, p3604, 12p |
| Abstrakt: |
Simple Summary: Bats represent a vast number of species, and Chiroptera is the second most diverse order of mammals. Desmodus rotundus, or the common vampire bat, is the most studied haematophagous species, as it is the primary host of the rabies virus in Latin America. Through high-throughput sequencing, we identified and characterized three novel members and a potential new genus of the Papillomaviridae family, named DrPV-1, DrPV-2, and DrPV-3. Papillomaviruses are capable of infecting many vertebrates, including bats, and can occasionally cause cancer. These findings contribute to the characterization of papillomaviruses in understudied groups such as bats, particularly in D. rotundus, whose viral diversity is often biased toward rabies detection. To the best of the authors' knowledge, this is the first description of papillomaviruses in D. rotundus. Bats are mammals with high biodiversity and wide geographical range. In Brazil, three haematophagous bat species are found. Desmodus rotundus is the most documented due to its role as a primary host of rabies virus in Latin America. Bats are known to harbor various emerging viruses causing severe human diseases. Beyond zoonotic viruses, these animals also harbor a diversity of non-zoonotic viruses. Papillomaviruses are circular double-stranded deoxyribonucleic acid (dsDNA) viruses that infect the epithelial and mucosal cells of many vertebrates, occasionally causing malignant lesions. High-throughput sequencing has enabled papillomaviruses discovery in different bat species. Here, 22 D. rotundus samples were collected through the rabies eradication program in Rio Grande do Sul. The DNA extracted from pooled intestines was amplified by the rolling-circle amplification (RCA) method and sequenced using the Illumina® MiSeq platform (San Diego, CA, USA).Analysis revealed three contigs corresponding to the Papillomaviridae family, representing three novel viruses named DrPV-1, DrPV-2, and DrPV-3. Phylogenetic analysis suggests DrPV-1 may constitute a new species within the Dyophipapillomavirus genus, while DrPV-2 and DrPV-3 may represent different types within the same species from a novel genus. This is the first description of a papillomavirus in the D. rotundus species, contributing to the characterization of PVs in the Chiropteran order. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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