Slow Negative Potentials in the Pre-Stimulus Period in Healthy Subjects and Patients with their First Episode of Schizophrenia.

Autor: Slavutskaya, M. V., Lebedeva, I. S., Fedotova, A. A., Tikhonov, D. V., Kaleda, V. G.
Předmět:
Zdroj: Human Physiology; Jun2024, Vol. 50 Issue 3, p209-218, 10p
Abstrakt: Behavioral data (number and nature of erroneous responses, LP of saccades to the "Go" stimulus) indicate a significant decrease in the efficiency of task performance in patients with their first episode of schizophrenia, compared to healthy subjects. At the same time, in the group of patients, an increase in the amplitude of the slow negativity components (SNP1, SNP2, SNP3) in the 1-s pre-stimulus interval was shown, which may reflect a compensatory increase in the activation of the cortical networks of predictive attention and proactive inhibition to improve the effectiveness of the response. Intergroup differences in the topography of the peaks of the SNP1 and 2 components suggest "disorganization" of the cortical networks of cognitive control of the left hemisphere at an early stage of schizophrenia. It is assumed that the SNP1, SNP2, and SNP3 components can be considered as potentially clinically significant markers of cognitive control disorders in schizophrenia. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: