| Abstrakt: |
Despite the folk medicine and pharmaceutical applications of Forsskaolea tenacissima L., its essential oil (EO) was not investigated. Herein, the chemical characterization of EO of the F. tenacissima aerial parts from Saudi Arabia using GC-FID and GC-MS analysis was done. This study also investigates the allelopathic effects of the EO on the two noxious weeds, Dactyloctenium aegyptium and Bidens pilosa. In addition, docking studies of the EO's main compounds have been carried out on 4-hydroxyphenylpyruvate dioxygenase and Auxin Binding Protein 1. The predominant ingredients of the oil were found to be sesquiterpenes, accounting for 86.44% of its mass, among the 38 compounds that were identified. The main components were identified as β-eudesmol, bulnesol, isolongifolol, hexahydrofarnesyl acetone, and chavicol, with respective relative concentrations of 57.27, 8.91, 5.59, 4.47, and 4.24%. The results have demonstrated a dose-dependent allelopathic potential on the germination of seeds and the seedling growth of shoots and roots of both weeds. F. tenacissima EO showed significant phytotoxic effects on the seeds germination and the shoots and roots seedling growth of D. aegyptium and B. pilosa weeds, with corresponding IC50 values of 79.7, 97.2, and 65.2 μL L−1. and 41.93, 54.54 and 51.39 μL L−1, respectively. The in-silico studies revealed the good binding affinity of geranylgeraniol to both enzymes, 4-hydroxyphenylpyruvate dioxygenase and Auxin Binding Protein 1, with ΔGa = −6.95 and −6.48 kcal/mol, respectively. So, the essential oil of F. tenacissima and its components could be considered a good bioherbicide to avoid the detrimental effects of the traditional one. [ABSTRACT FROM AUTHOR] |
