| Autor: |
Pajonk, Frank-Gerald, Kessler, Holger, Supprian, Tillmann, Hamzei, Pegah, Bach, Daniela, Schweickhardt, Janina, Herrmann, Wolfgang, Obeid, Rima, Simons, Andreas, Falkai, Peter, Multhaup, Gerd, Bayer, Thomas A. |
| Předmět: |
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| Zdroj: |
Journal of Alzheimer's Disease; 2005, Vol. 8 Issue 1, p23-27, 5p, 3 Graphs |
| Abstrakt: |
Alzheimer's disease (AD) is a devastating brain disorder clinically characterised by progressive loss of characteristic cognitive abilities. Increasing evidence suggests a disturbed copper (Cu) homeostasis to be associated with the pathological processes. In the present study we analysed the plasma Cu levels and cognitive abilities using the Alzheimer's disease Assessment Scale-cognitive subscale (ADAS-cog) in 32 patients with mild to moderate AD. Statistical analysis revealed a negative correlation between plasma Cu levels and cognitive decline (r=-0.49; P<0.01). Patients with low plasma Cu (mean 82 +/- SD 9) had significant higher ADAS-cog values (mean 23 +/- SD 7), than patients with medium plasma Cu (mean 110 +/- SD 7), who exhibited lower ADAS-cog scores (mean 16 +/- SD 4; ANOVA, P<0.0001). Despite the fact that all patients had plasma Cu levels within the physiological range between 65 microg and 165 microg/dL, 87.5% of the patients revealed a significant negative correlation between plasma Cu and ADAS-cog. This finding supports the hypothesis of a mild Cu deficiency in most AD patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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