| Autor: |
Xiong, Bin, Zhang, Junfeng, Si, Yanmei, Fu, Jia |
| Zdroj: |
Discover Oncology; 12/18/2024, Vol. 15 Issue 1, p1-13, 13p |
| Abstrakt: |
Objective: A lack of effective delivery methods has hampered the study of therapeutics targeting miR-875-5p for breast cancer (BC). Methods: The miR-875-5p mimic was conjugated to AuNPs to produce AuNP-miR-875-5p. Then, the effect of AuNP-miR-875-5p on the proliferative, migratory, invasive activities, and apoptosis of BC cells was detected, as well as on tumor growth in animals. The involvement of the MTDH/PTEN/AKT pathway in miR-875-5p-mediated BC progression was identified. Results: AuNP-miR-875-5p was delivered to BC cells and hampered cell malignancy. MTDH was targeted by miR-875-5p. MTDH expression was negatively correlated with miR-875-5p expression in BC tissues. The anti-tumor effect of AuNP-miR-875-5p in BC cells was counteracted by MTDH overexpression. AuNP-miR-875-5p enhanced PTEN protein expression, thereby inhibiting AKT activation by targeting MTDH. AuNP-miR-875-5p blocked MCF-7 tumor growth in vivo. Conclusion: AuNPs can deliver miR-875-5p to BC cells, and AuNP-miR-875-5p has clinical potential for treating unresectable BC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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