Recent Studies from University of Normandie Add New Data to Follicular Lymphoma (Aberrant Isotype Class Switch Recombination Reactivation Leads to a Genome Wide Genomic Instability in Follicular Lymphoma).

Předmět:	LYMPHATIC diseases LYMPHOPROLIFERATIVE disorders FOLLICULAR lymphoma GENETICS DIFFUSE large B-cell lymphomas IMMUNOGLOBULIN class switching
Zdroj:	Hematology Week; 12/23/2024, p1419-1419, 1p
Abstrakt:	A recent study from the University of Normandie in France explores the genetic instability processes driving lymphomagenesis in follicular lymphoma (FL) patients. The research reveals that aberrant isotype class switch recombination (CSR) reactivation leads to genome-wide genomic instability in FL, potentially contributing to tumor aggressiveness and clinical progression. The study suggests that understanding these molecular mechanisms is crucial for anticipating relapses and resistances to therapies in FL patients. For more information, the full article can be accessed for free at https://doi.org/10.1182/blood-2024-203479. [Extracted from the article]
Databáze:	Complementary Index
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