New Findings on Molecular Oncology Described by Investigators at University of Toronto (Viral Mimicry Evasion: a New Role for Oncogenic Kras Mutations).

Předmět:	MOLECULAR oncology IMMUNE checkpoint inhibitors INTERFERON gamma MEDICAL physics DOUBLE-stranded RNA
Zdroj:	Cancer Weekly; 12/24/2024, p729-729, 1p
Abstrakt:	Researchers at the University of Toronto have identified a new role for oncogenic Kras mutations in evading viral mimicry, which is crucial for malignant transformation. The study found that KRAS mutations downregulate the RNA-binding protein DDX60, inhibiting interferon signaling and promoting tumor growth. This research suggests that targeting KRAS could enhance the effectiveness of immune checkpoint inhibition therapy in colorectal cancer models. [Extracted from the article]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu