| Autor: |
Punhani, Pallavi, Ahluwalia, Charanjeet, Agrawal, Meetu, Kandwal, Preeti |
| Zdroj: |
Archives of Breast Cancer; Nov2024, Vol. 11 Issue 4, p371-377, 7p |
| Abstrakt: |
Background: The study aims to evaluate CD44 expression as a cancer stem cell marker in Triple-negative breast cancer (TNBC) and its correlation with prognostic parameters. Evaluation of CD44 immunoexpression in TNBC is vital for understanding tumor aggressiveness and determining its prognostic value. Methods: In this hospital-based cross-sectional study of 50 cases of primary triple negative breast cancer patients, the tissue sections were subjected to immunohistochemical examination using CD44 antigen marker. The proportion and intensity of CD44 immunostaining were assessed and correlation with prognostic markers such as histological grade, tumor size and nodal status was examined. Results: CD44 expression was observed in 40% of the total cases with a statistically significant association with histological grade (P= 0.002). Higher CD44 expression was noticed with increasing tumour grade. However, no statistical significance was observed with respect to tumor size and nodal status. Conclusion: The study suggests that CD44 immunoexpression may serve as a surrogate marker of BCSCs and may hold prognostic value in TNBC patients. However, further studies on larger samples are required to fully understand its role. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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