DMSO–K2S2O8 mediated iodine-free conversion of glycal C-3 ether to 3-enopyranones: synthesis of furo[3,2-c] pyrans.

Autor: Rasool, Bisma, Kundu, Sanchari, Zargar, Irshad Ahmad, Mukherjee, Debaraj
Předmět:
Zdroj: Chemical Communications; 1/4/2025, Vol. 61 Issue 1, p137-140, 4p
Abstrakt: A straightforward, highly efficient, and regioselective method for directly converting 3-O-benzylated and silylated glycals into their corresponding enones has been developed using a DMSO–K2S2O8 reagent system. This reaction is scalable to gram quantities under mild conditions, achieving up to 80% yields. The resulting enones are valuable intermediates for the synthesis of furo[3,2-c] pyrans, which are integral components of various biologically significant scaffolds. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index