| Abstrakt: |
Forensic chemistry integrates analysis of toxic substances and drugs in either seized materials or biological samples and is therefore crucial for investigating crimes and identifying lethal intoxication cases. Over the past decade, high-performance thin-layer chromatography (HPTLC) has emerged as a cost-effective, simple, and efficient analytical technique in forensic laboratories. This review comprehensively examines the applications of HPTLC in forensic chemistry, focusing on its versatility and advantages in drug analysis and toxin identification. HPTLC offers benefits such as minimal sample requirements, high precision, simultaneous analysis of multiple samples, and reduced solvent consumption compared with traditional methods such as high-performance liquid chromatography (HPLC) and gas chromatography‒mass spectrometry (GC‒MS). Specific applications discussed include the analysis of cannabinoids in Cannabis sativa L., where HPTLC is employed for profiling and quantifying tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN). The review encompasses studies on synthetic cannabinoids, benzodiazepines, and other prescription drugs, highlighting the role of HPTLC in forensic drug analysis. Methodologies combining HPTLC with advanced techniques such as mass spectrometry and chemometrics demonstrate its efficacy in identifying and quantifying substances crucial for forensic investigations. This paper underscores the robustness, reliability, and practicality of HPTLC across various forensic applications, emphasizing its significance as a valuable tool in modern forensic chemistry for both routine analyses and complex forensic investigations. [ABSTRACT FROM AUTHOR] |
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