| Autor: |
Choudhury, Abhishek, Chatterjee, Soumya, Dalui, Shauryabrota, Ghosh, Pronabesh, Daptary, Altamas Hossain, Mollah, Golam Kibria, Bhattacharyya, Arindam |
| Zdroj: |
Cell Biology International; Jan2025, Vol. 49 Issue 1, p45-54, 10p |
| Abstrakt: |
Cytotoxic CD8+ T cells plays a pivotal role in the adaptive immune system to protect the organism against infections and cancer. During activation and response, T cells undergo a metabolic reprogramming that involves various metabolic pathways, with a predominant reliance on glycolysis to meet their increased energy demands and enhanced effector response. Recently, extracellular vesicles (EVs) known as exosomes have been recognized as crucial signaling mediators in regulating the tumor microenvironment (TME). Recent reports indicates that exosomes may transfer biologically functional molecules to the recipient cells, thereby facilitate cancer progression, angiogenesis, metastasis, drug resistance, and immunosuppression by reprogramming the metabolism of cancer cells. This study sought to enlighten possible involvement of cancer‐derived exosomes in CD8 + T cell glucose metabolism and discover a regulated signalome as a mechanism of action. We observed reduction in glucose metabolism due to downregulation of AKT/mTOR signalome in activated CD8 + T cells after cancer derived exosome exposure. In‐vivo murine breast tumor studies showed better tumor control and antitumor CD8 + T cell glycolysis and effector response after abrogation of exosome release from breast cancer cells. Summarizing, the present study establishes an immune evasion mechanism of breast cancer cell secreted exosomes that will act as a foundation for future precision cancer therapeutics. Highlights: Breast cancer‐derived exosomes reduce activated CD8 + T‐cell glycolysisExosomes target Akt/mTOR/Glut1 axis for glycolytic depletion of activated CD8 + T cellsReduced glycolysis of CD8 + T cell lessens effector response and elicit tumor burdenExosome blockade restores glycolysis and effector response of CD8 + T cells to some extent [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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