| Autor: |
Thorn, Andrea, Seem, Kristoffer Michael, Talman, Maj-Lis, Engelmann, Bodil E., Sørensen, Michala Skovlund, Aggerholm-Pedersen, Ninna, Baad-Hansen, Thomas, Petersen, Michael Mørk |
| Zdroj: |
Cancers; Dec2024, Vol. 16 Issue 23, p4077, 12p |
| Abstrakt: |
Simple Summary: Soft-tissue sarcomas (STSs) are rare cancers that are difficult to diagnose and treat due to their variability. In 2009, Denmark introduced the Cancer Patient Pathways for sarcomas (CPPs) to improve the survival of sarcoma patients by accelerating the diagnosis and treatment processes. This study examined whether the CPPs improved survival in patients with high-grade STSs. Our findings show that survival has improved since the CPPs were introduced and treatment delays have been reduced. This research highlights the importance of streamlined cancer care in improving patient outcomes. Background: Soft-tissue sarcomas (STSs) are rare and challenging to diagnose due to their heterogeneous presentation. In 2009, Denmark introduced the Cancer Patient Pathways for sarcomas (CPPs) to improve sarcoma treatment by streamlining diagnostic and therapeutic processes. The primary objective of this study is to evaluate the impact of the CPPs on the overall survival of patients with deep-seated, high-grade STSs, comparing outcomes from before and after CPP implementation. Methods: A retrospective cohort study was conducted using data from 712 patients diagnosed with high-grade STSs in the extremities or trunk wall between 2000 and 2018. Patients were grouped into pre-CPP (2000–2008) and post-CPP (2010–2018) cohorts. Overall survival was analyzed using Kaplan–Meier estimates. Results: The five-year overall survival improved from 43% in the pre-CPP cohort to 52% post-CPP (p = 0.05). Time-to-treatment was significantly reduced in the post-CPP cohort, with a median decrease of 3 days (18 vs. 15 days, p < 0.001). We found only a very weak tendency toward larger tumor sizes in the pre-CPP cohort and no difference regarding the percentage of patients that had distant metastases at diagnosis between cohorts. In the post-CPP cohort, the percentage of whoops operations decreased and the use of oncological services increased. Conclusions: After the introduction of the CPPs for the sarcoma patients, overall survival improved and time to treatment was reduced. This study highlights the importance of efficient referral pathways in improving cancer outcomes but cannot exclude that other factors could also have contributed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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