| Autor: |
Cotan, Horia T., Emilescu, Radu A., Iaciu, Cristian I., Orlov-Slavu, Cristina M., Olaru, Mihaela C., Popa, Ana M., Jinga, Mariana, Nitipir, Cornelia, Schreiner, Oliver Daniel, Ciobanu, Romeo Cristian |
| Zdroj: |
Cancers; Dec2024, Vol. 16 Issue 23, p3928, 35p |
| Abstrakt: |
Simple Summary: This systematic review explores prognostic and predictive factors in colorectal cancer, aiming to identify key determinants that influence patient outcomes and treatment responses. By synthesizing evidence from relevant studies, the review assesses the impact of various factors such as tumor characteristics, biomarker expression, and treatment modalities on disease prognosis and therapeutic efficacy. Through a comprehensive analysis, this review provides valuable insights into the factors that can help clinicians tailor treatment strategies and improve patient outcomes in colorectal cancer management. Colorectal cancer (CRC) remains a significant global health burden, necessitating a thorough understanding of prognostic and predictive factors to enhance patient outcomes. This systematic review aims to comprehensively evaluate prognostic and predictive determinants in CRC, encompassing both traditional and emerging biomarkers. A systematic search of major electronic databases was conducted to identify relevant studies published from 1995 up to 2024. Eligible articles were critically appraised, and data extraction was performed according to predefined criteria. The prognostic determinants examined included clinicopathological features such as tumor stage, grade, and lymph node involvement, as well as molecular biomarkers including RAS, BRAF, and MSI status. Predictive determinants encompassed biomarkers influencing response to targeted therapies and immunotherapy, such as HER2 and Immunoscore. The review also explores novel prognostic and predictive markers, including tumor microenvironment characteristics and liquid biopsy-based biomarkers. Synthesizing evidence from diverse studies, this review provides insights into the prognostic and predictive landscape of CRC, highlighting the potential clinical implications of identified determinants. Understanding the multifaceted nature of prognostic and predictive factors in CRC is imperative for the advancement of personalized treatment strategies and improvement of patient outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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