Buruli ulcer in Australia: Evidence for a new endemic focus at Batemans Bay, New South Wales.

Autor: Hossain, Mehrab E, Keighley, Caitlin, Buultjens, Andrew H., Porter, Jessica L., Johnson, Paul D. R., Stinear, Timothy P., Globan, Maria, Lavender, Caroline J., Lacey, Jake A., Sherry, Norelle L., Forsyth, Anton, Formby, Mark, Marr, Ian
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Zdroj: PLoS Neglected Tropical Diseases; 12/13/2024, Vol. 18 Issue 12, p1-12, 12p
Abstrakt: We describe two locally acquired cases of Mycobacterium ulcerans infection (Buruli ulcer) in the town of Batemans Bay on the east coast of New South Wales (NSW), Australia, 150 km north of Eden, the only other place in NSW where Buruli ulcer has likely been locally acquired. Genomic analysis showed that the bacterial isolates from the cases were identical but belonged to a phylogenetically distinct M. ulcerans clade that was most closely related to the isolate from the earlier case in Eden to the south. It is proposed that Batemans Bay is a new endemic focus of human Buruli ulcer transmission. Author summary: Mycobacterium ulcerans causes Buruli ulcer, a progressive infection affecting skin and subcutaneous soft tissues. Although predominantly reported in central and west Africa, Australia, and Japan, new endemic regions for Buruli ulcer continue to be discovered. In Australia, the state of Victoria has seen a significant public health challenge with Buruli ulcer, where evidence points to zoonotic transmission from native possums to humans via mosquitoes. Recently, a new location of locally acquired Buruli ulcer has been identified in Batemans Bay, New South Wales (NSW), Australia. Genome sequencing of cases in this area has revealed a distinct M. ulcerans genotype, suggesting the pathogen is extant in NSW similar to the situation in Victoria. Surveys of possum excreta in Batemans Bay have confirmed the presence of M. ulcerans, indicating its establishment in a local wildlife reservoir in a new endemic region. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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