| Autor: |
Abd Elghany, Amira Ahmed, Massoud, Yasmine Mahmoud, Bahaa El-Din Ahmed, Mohamed Mohamed, Ebada, Hend El Saied |
| Zdroj: |
QJM: An International Journal of Medicine; 2024 Supplement, Vol. 117, pii427-ii428, 2p |
| Abstrakt: |
Background: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) has a substantial risk of morbidity and mortality. Liver transplantation has faced unique challenges due to COVID-19 all over the world. There is a scarce data on the effects of SARSCoV-2 infection in candidates awaiting liver transplantation or potential donors who proved to have SARS CoV-2 infection based on clinical and/or positive RT-PCR test and/or radiological data. Objective: To describe the effect of preoperative SARS-CoV 2infection in potential candidates and living donors on the outcome of living donor liver transplantation (LDLT). Patients and Methods: Combined retrospective and prospective pilot cohort study carried out at Ain Shams Center for Organ Transplantation (ASCOT). 74 LDLT recipients & their donors were included, who underwent LDLT operation during the interval between January 2020 and august 2022. were classified into two groups: Group A: included candidate recipients and/or living donor who had preoperative SARS-CoV-2 infection and Group B (control group): included candidate recipients and/or living donor who didn't have preoperative SARS-CoV-2 infection. The two groups were followed post LDLT for a minimum duration of 6 months and maximum duration of 2.5 years. Their data were analysed and compared. Results: Among the 74 LDLT recipients, 10 recipients (13.5%) & 8 donors (10.8%) had confirmed preoperative SARS-COV2. The mean age of the recipients was 46.90 6 14.15 years old with male prevalence, and the majority had mild respiratory symptoms of preoperative COVID-19. Two patients have specific treatment for COVID-19 with remdesivir or steroid therapy and supplemental oxygen and 8 patients received only symptomatic treatment. The median time between SARS Cov2 infection and LT in our series was 6.5 months. there was no significant difference between candidates/recipients who had preoperative COVID-19 (group-a) and those who hadn't (group-b), regarding the preoperative, operative and postoperative characteristics apart from significantly shorter duration of operation and higher incidence of early postoperative desaturation in ICU in (group a, 20% vs 1.6% in group b patients, p: 0.006) Table (1). The mean age of the living donors of group a was 30.25 6 7.07, all had mild preoperative COVID 19 disease which didn't affect significantly their operative and postoperative course Table (2). Conclusion: Mild preoperative COVID-19 disease didn't affect significantly the postoperative course of recipients for LDLT. Donors with completely resolved mild preoperative COVID-19 disease can safely donate for LDLT. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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