| Autor: |
Gujarathi, Rahul, Chavan, Yogita, Arora, Manish, Deshpande, Shailesh, Kulkarni, Akshar, Nilakhe, Savita |
| Zdroj: |
African Journal of Biomedical Research; Sep2024, Vol. 27 Issue 3, p501-509, 9p |
| Abstrakt: |
Pain in neonates can be treated with pharmacological as well as non-pharmacological interventional approaches. Under the nonpharmacological pain relief strategies, like non-nutritive sucking, swading, facilitated tucking, oral administration of sucrose, breast feeding and skin to skin contact etc. are the convenient and inexpensive methods which can be adopted without physicians recommendations or prescriptions and are supposed to be well tolerated by infants. Whereas pharmacological methods of neonatal pain relief contains local anesthetics, pre-operative pain subsiding agents like opioids (Morphine) and opioid antagonists, sedatives or hypnotics, vapor anesthetics, NSAIDs and non-opioid analgesics like Acetaminophen. Non pharmacological interventions are better and feasible alternatives to pharmacological methods, concerned to its risk of adverse effects which is minimum. Sucrose and glucose, the most popular substances used for sweet-tasting solutions; as they are effective and easy to use, having no documented adverse effects; also, sucrose and glucose are as inert of pharmacologically neutral substances. The use of orally administered sweet tasting solutions in the management for neonatal pain in the clinical set up is widespread practice which is recommended in both national as well as international guidelines. Though there is no completely acceptable explanation on the pain-reducing effect of these sweet-tasting solutions, but certain mechanisms like activation of endogenous opioids is suggested as a possible mode of actions. Plenty of plant origin drugs are proven to have a analgesics effect in adults with no documented adverse reactions of any kind. These plant origin analgesics are in use since ages and recorded in ancient medical sciences like Ayurveda, Unani and Chinese Medicine. These plant origin analgesics are needed to be evaluated as a choice of drug in neonates during procedural pain stimulus. The particular study being discussed here has evaluated the pain perception and analgesic activity of Mocharasa (Gum resin of Bombax malbaricum or Bombax ceiba) in neonates and validated and established using pain assessment scales. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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