Versatile synthesis of 2-functionalized dihydrothiazolo[2,3-b]quinazolines through regioselective electrophilic intramolecular heterocyclization of 3-alkenyl-2-thioxoquinazolin-4-ones.

Autor: Kut, Diana Zh., Kut, Mykola M., Ostapchuk, Eugeniy M., Onysko, Mikhajlo Yu., Onys'ko, Petro P., Lendel, Vasil G.
Zdroj: Phosphorus, Sulfur & Silicon & the Related Elements; 2024, Vol. 199 Issue 7-9, p675-682, 8p
Abstrakt: Electrophilic intramolecular heterocyclizations of 3-alkenyl-2-thioxoquinazolin-4-ones, induced by halogens, NBS, sulfuryl chloride, protic acids, selenium, or tellurium halides, proceed with high regioselectivity. This process leads to the formation of 2-functionalized dihydrothiazolo[2,3-b]quinazolines, showcasing the versatility and reliability of this synthetic route across various electrophilic reagents. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index