| Abstrakt: |
The Ayurvedic formulation "Dashamoola" is used for the treatment of chronic inflammatory degenerative diseases like rheumatoid arthritis (RA). The present study intends to evaluate the anti-arthritic effect of Dashamoola on Freund's complete adjuvant (FCA)-induced arthritis in female Swiss albino mice. Dashamoola kwath was prepared and characterized for physicochemical properties. Female Swiss albino mice (25.61 ± 0.13 gm; n = 36) were divided into 6 treatment groups. Arthritis was induced in mice from 5 treatment groups (Groups II–VI) by a single intradermal FCA injection (0.1 mL) into the left hind paw except the control (Group I). After 7 days, Indomethacin (3 mg/kg, Group III) and different doses of Dashamoola (Group IV: 500, Group V: 700, Group VI: 1000 mg/kg body weight) were administered through oral gavage for 14 days. Mice in group II were not exposed to any treatment drug. After 14 days, parameters such as paw volume, body weight, haematology, erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), rheumatoid factor (RF) were assessed. The ankle joint was also extracted for histopathology and radiography. Paw volume, ESR, CRP, RF, WBC total count increased significantly (p < 0.05), while body weight, haemoglobin, RBC reduced significantly (p < 0.05) in group II mice compared to group I. Dashamoola treatment significantly (p < 0.05) improved all the physical and biochemical parameters in arthritic mice to near normal conditions, and 1000 mg/kg dose showed the most effective results. Dashamoola treatment significantly attenuated FCA-induced radiographical and histopathological alterations of the ankle joint. Dashamoola showed anti-arthritic effects akin to the standard synthetic drug Indomethacin. [ABSTRACT FROM AUTHOR] |
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