Measurement properties of the German version of the Cambridge examination for mental disorders of older people with Down syndrome and others with intellectual disabilities (CAMDEX-DS).
| Autor: | Loosli, Sandra V., Neumann, Lennart C., Wlasich, Elisabeth, Prix, Catharina, Koll, Laura, Weidinger, Endy, Vöglein, Jonathan, Wagemann, Olivia, Danek, Adrian, Nübling, Georg, Levin, Johannes |
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| Předmět: |
ALZHEIMER'S disease diagnosis
DIAGNOSIS of dementia CROSS-sectional method MULTITRAIT multimethod techniques DOWN syndrome COGNITIVE testing RESEARCH funding RESEARCH methodology evaluation SCIENTIFIC observation RESEARCH evaluation INTERVIEWING PILOT projects DESCRIPTIVE statistics INTELLECTUAL disabilities CAREGIVERS NEUROPSYCHOLOGICAL tests PSYCHOMETRICS RESEARCH methodology STATISTICAL reliability COMPARATIVE studies SENSITIVITY & specificity (Statistics) DEMENTIA patients INTER-observer reliability DISEASE complications ADULTS |
| Zdroj: | Journal of Intellectual & Developmental Disability; Dec2024, Vol. 49 Issue 4, p402-414, 13p |
| Abstrakt: | Background: The CAMDEX-DS is an instrument to diagnose Alzheimer's disease (AD) in Down syndrome consisting of an informant interview and a cognitive test battery (CAMCOG-DS). Measurement properties of the German CAMDEX-DS were investigated. Method: Fifty-five adults with Down syndrome (19–58 years) participated in this observational study. "Dementia" and "Alzheimer's dementia" (Alzheimer's disease) were diagnosed clinically and operationalised CAMDEX-ICD-10 criteria were applied to evaluate criterion validity. Validity and reliability of the CAMCOG-DS were analysed. Results: Specificity of the interview was 69–93%; sensitivity 0–80% for "dementia"; and 0-20% for Alzheimer's disease. A complete CAMCOG-DS score was obtained in 85% (item difficulty 0.11–0.96). Construct validity and retest-reliability were low to moderate (τ =.04–.79), inter-rater reliability excellent (τ =.70–.89), internal consistency and selectivity acceptable to excellent. Conclusions: Currently, the CAMDEX-DS including the CAMCOG-DS are the outcome assessments for assessing dementia in Down syndrome with the best psychometric properties; however, revision is recommended. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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