| Autor: |
Shen, Yao-Bin, Zhuang, Qian-Hao, Wang, Xiao-Lin, An, Xiao-De, Qiu, Bin, Shi, Tiesheng, Xiao, Jian |
| Předmět: |
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| Zdroj: |
Green Chemistry; 12/21/2024, Vol. 26 Issue 24, p11899-11907, 9p |
| Abstrakt: |
The development of green and efficient methods for the construction of azepinoindole skeletons remains highly desirable yet challenging. Described herein are the EtOH-mediated cascade C(sp3)–H alkylation reactions of 4-dialkylamino-indole-3-carbaldehydes for green and divergent synthesis of spirocyclic azepino[4,3,2-cd]indole derivatives. This protocol proceeded through a cascade in situ assembly of pre-aromatics/aromatization-driven [1,6]-hydride transfer/cyclization sequence, which exhibited many advantages such as green bio-sourced EtOH as the reaction medium, metal-free and redox-neutral conditions, high step-/atom-economy, water as waste, high yields, excellent diastereoselectivities (up to >20 : 1 dr), a wide substrate scope, and diverse transformations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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