Copper-Catalyzed [4+1] and [4+2] Reactions through Tandem -Remote Propargylation/Cyclization/Isomerization with an Amine or a Hydrazine.

Autor: Sun, Yu-Ze, Lin, Guo-Qiang, He, Zhi-Tao
Předmět:
Zdroj: Synlett; Jan2025, Vol. 36 Issue 1, p82-86, 5p
Abstrakt: Two novel copper-catalyzed cyclization reactions involving a remote propargylic substitution/cyclization/isomerization cascade are disclosed. Derivatives of the seldomly studied heterocycles thieno[2,3- c ]pyrrole and thieno[2,3- d ]pyridazine are conveniently synthesized in moderate to good yields from primary amines or arylhydrazines through [4+1] and [4+2] reactions, respectively. Preliminary mechanistic experiments corroborated the occurrence of the designed cascade reactions. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index