| Autor: |
Khatoon, Rafia, Jandial, Tanvi, Gupta, Anish, Kundan, Sujata, Sridharan, Vellaisamy |
| Předmět: |
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| Zdroj: |
Synthesis; Jan2025, Vol. 57 Issue 1, p218-228, 11p |
| Abstrakt: |
An efficient one-pot, two-step synthesis of structurally diverse 4-indolyl-/pyrrolyl-chromanes was developed starting from o -propargylated salicylaldehydes, 2,6-dialkylphenols and indoles/pyrrole. This process begins with a sequential secondary amine-catalyzed formation of p -quinone methides followed by Brønsted acid catalyzed 1,8-addition with indoles/pyrrole to access the functionalized chromanes in high yields (up to 91%). This sequential reaction generates three new C–C bonds, shows high step- and atom-economy with only one molecule of water as the side product and gives access to complex molecular frameworks without the need for the isolation of the intermediates. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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