| Autor: |
Benga, Laurentiu, Rehm, Anna, Gougoula, Christina, Westhoff, Philipp, Wachtmeister, Thorsten, Benten, W. Peter M., Engelhardt, Eva, Weber, Andreas P. M., Köhrer, Karl, Sager, Martin, Janssen, Stefan |
| Předmět: |
|
| Zdroj: |
Microbiome; 12/5/2024, Vol. 12 Issue 1, p1-20, 20p |
| Abstrakt: |
Background: The microbiome greatly affects health and wellbeing. Evolutionarily, it is doubtful that a host would rely on chance alone to pass on microbial colonization to its offspring. However, the literature currently offers only limited evidence regarding two alternative hypotheses: active microbial shaping by host genetic factors or transmission of a microbial maternal legacy. Results: To further dissect the influence of host genetics and maternal inheritance, we collected two-cell stage embryos from two representative wild types, C57BL6/J and BALB/c, and transferred a mixture of both genotype embryos into hybrid recipient mice to be inoculated by an identical microbiome at birth. Conclusions: Observing the offspring for six generations unequivocally emphasizes the impact of host genetic factors over maternal legacy in constant environments, akin to murine laboratory experiments. Interestingly, maternal legacy solely controlled the microbiome in the first offspring generation. However, current evidence supporting maternal legacy has not extended beyond this initial generation, resolving the aforementioned debate. BvkFmArGExF4DhB6h6D8wq Video Abstract [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink