| Abstrakt: |
A recent study conducted at Instituto Politecnico Nacional in Reynosa, Mexico, focused on evaluating the antiprotozoal activity and mechanism of action of n-butyl and iso-butyl ester of quinoxaline-1,4-di-N-oxide derivatives against Giardia lamblia, Trichomonas vaginalis, and Entamoeba histolytica. The research identified compound T-167 as having the best giardicidal activity, while compounds T-142 and T-143 showed the best amoebicidal and trichomonacidal activity, respectively. The study also highlighted compounds T-145 and T-161 as the best inhibitors of EhTrxR. This research provides valuable insights into potential broad-spectrum antiparasitic agents for these infectious diseases. [Extracted from the article] |
