| Abstrakt: |
Background: Age-related cataracts are a leading cause of visual impairment worldwide, with multiple risk factors contributing to their development. Emerging evidence suggests a possible link between oxidative stress-related biomarkers, such as serum uric acid, and cataract formation. Elevated uric acid levels, often associated with systemic oxidative stress, may influence lens opacity, but this association remains underexplored. Objective: This observational study investigates the association between serum uric acid levels and age-related cataract formation, aiming to assess serum uric acid as a potential risk factor for cataracts. Methods: A sample of 100 participants (mean age: 65.3 ± 8.4 years; 45% male, 55% female) was recruited. Participants were grouped into four age categories (50-59, 60-69, 70-79, and 80+). Serum uric acid levels were measured, and cataract presence was documented. Correlation and logistic regression analyses assessed the association between serum uric acid levels, age, and cataract presence. Results: Cataract prevalence was 58%, increasing by age group: 32% (50-59 years), 60% (60-69 years), 72% (70-79 years), and 80% (80+ years). Participants with cataracts had higher mean serum uric acid levels (6.1 ± 1.3 mg/dL) compared to those without (5.4 ± 1.4 mg/dL, p < 0.05). Correlation analysis indicated a moderate positive association between serum uric acid and cataract formation (r = 0.42, p < 0.05). Logistic regression showed each 1 mg/dL increase in uric acid increased cataract risk by 1.2-fold (OR = 1.2, 95% CI: 1.1-1.5, p < 0.05). Conclusion: Elevated serum uric acid levels are significantly associated with age-related cataract formation, highlighting its potential role in cataract risk. Further studies are recommended to explore interventions targeting uric acid reduction. [ABSTRACT FROM AUTHOR] |
