| Autor: |
Zaiats, O. V., Voronych-Semchenko, N. M., Kryvenkyi, Т. Р. |
| Předmět: |
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| Zdroj: |
Physiological Journal / Fiziologichnyi Zhurnal; 2024, Vol. 70 Issue 5, p56-65, 10p |
| Abstrakt: |
Proper supply of bioelements that participate in physiological processes is especially important in childhood, because it significantly affects for the formation of the hormonal profile. The prevalence of dental pathology among schoolchildren reflects the priority of early diagnosis and thorough prevention of pathological processes. In order to find out the risks of dental health disorders, the intensity of nitroso-oxidative processes in the oral fluid of children (boys and girls aged 6-11 and young men and girls aged 12-18) with combined latent iron and mild iodine deficiency was studied and in conditions of sufficient supply of trace elements (control group). As a result of the study, the activation of the peroxidation processes of proteins (the level of products of oxidative modification of proteins increases by 87.3% - 3.3 times) and lipids (the content of diene conjugates increases by 62.7% - 12.4 times) in case of imbalance of antioxidant protection of oral fluid (inhibition of SOD by 20.4-30.7%, activation of glutathione peroxidase by 92.0-93.3%) compared to data in healthy teenagers. The development of iron and iodine deficiency is accompanied by an 8.3-fold increase in NO2- content, a 3.3-fold increase in the amount of NO2- and NO3- in the oral fluid of boys, and a 2.5-11.4-fold increase in the concentration of peroxynitrite in all schoolchildren compared to controls. An increase in H2S content in the oral fluid was also found in girls (by 25.6% compared to the values of the control group). The level of oxidative processes is higher in younger schoolchildren (ages 6-11). With age, the intensity of oxidative stress decreases, but changes in the NO metabolism system increase, especially for girls (cytotoxic peroxynitrite and H2S accumulate in the oral fluid). Therefore, it is possible to assert a high probability of the development of nitroso-oxidative stress in the conditions of a combination of iron and iodine deficiency already at the stage of preclinical changes, which can increase the risks of developing dental pathology. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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