| Autor: |
Kumar, Akshay, Bhagat, Stuti, Moar, Kareena, Singh, Sanjay, Dakal, Tikam Chand, Maurya, Pawan Kumar |
| Zdroj: |
BioNanoScience; Mar2025, Vol. 15 Issue 1, p1-10, 10p |
| Abstrakt: |
In this study, curcumin-encapsulated liposomes were evaluated in the red blood cells (RBCs) of different age groups. We conducted research on a sample of 38 healthy individuals of both sexes. We examined established aging biomarkers in red blood cells and tested the in vitro effect of curcumin liposomes against tert-butyl hydroperoxide (t-BHP), which induces oxidative stress. Our results show that liposome-encapsulated curcumin significantly (p < 0.05) decreases the malondialdehyde (MDA) and increases reduced glutathione (GSH) levels during aging. In silico biological target prediction of curcumin revealed that curcumin mainly targets monoamine oxidase A (MAOA). Our findings reveal that the curcumin liposome formulation gives a controlled release of curcumin in comparison to free curcumin in RBCs during the aging process. The finding has great potential in biomedical research for exploring curcumin-loaded liposomes as an anti-aging compound. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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