| Autor: |
Kromova, T. A., Zheltukhina, G. A., Nebol'sin, V. E., Kovaleva, V. L., Krzhechkovskaya, V. V., Evstigneeva, R. P. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Mar2005, Vol. 39 Issue 3, p122-125, 4p |
| Abstrakt: |
Natural endogenous compound γ- L-glutamylhistamine (γ-GHA) and its analogs γ-aminobutyrylhistamine and Nβ-glutarylhistamine were synthesized using peptide chemistry methods. The experiments in vivo on mice bearing a model of hypoxia with hypercapnia showed that all the synthesized compounds exhibit more or less pronounced antihypoxic activity. The most significant effect (150% relative to control) was observed for γ-GHA in a dose of 0.01 mg/kg, which is 2 × 104 times smaller than the effective dose of the reference drug sodium oxybutyrate. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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