Receptor subtype and outcome of breast cancer – Single-center experience from North India.

Autor: Banday, Saquib Z., Ayub, Maniza, Rasool, Malik T., Ahmed, Sheikh Z., Banday, Aaqib Z., Naveed, Shah, Guru, Faisal R., Mir, Mohmad H., Akhter, Shareefa, Bhat, Mudasir H., Yaseen, Syed B., Afroz, Fir, Bhat, Gull M., Lone, Mohammad M., Aziz, Shiekh A.
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Zdroj: Journal of Cancer Research & Therapeutics; Jul-Sep2024, Vol. 20 Issue 5, p1486-1493, 8p
Abstrakt: Aims/Objectives: In resource-limited settings, data regarding the impact of molecular/receptor subtypes on breast cancer (BC) are sparse. In this single-center retrospective study from north India, we analyze the outcomes of various molecular subtypes of BC. Materials and Methods: Females with biopsy-proven BC who were treated at our State Cancer Institute from 2014-2018 were included. Data regarding clinicopathological parameters and follow-up details were evaluated. For data analysis, cancers were categorized into 4 subtypes: HR+HER2–, HR+HER2+, HR–HER2+, and HR–HER2–. Results: Among 944 patients included, HR+HER2– (49.1%) and HR+HER2+ (13.1%) were the most and least common subtypes, respectively. The receptor subtype significantly impacted overall survival (OS). HR+HER2– cancers had the best outcomes while HR–HER2– cancers fared worst (3-yr OS of 94.3% and 69.1%, respectively). On subgroup analysis, the molecular subtype continued to significantly impact OS in patients with tumor grades II and III, disease stages II and III, and age groups of <40 and 40-60 years, respectively (HR–HER2– cancers had the lowest cumulative survival in each subgroup). In patients with metastatic BC, all molecular subtypes except HR+HER2– had a dismal prognosis. Conclusions: Overall and across various subgroups, patients with triple-negative BC had the poorest outcomes. Ensuring optimal treatment utilization including affordable access to personalized tailored therapy is the need of the hour to improve long-term outcomes in these patients. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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