Investigating the role of salivary Interleukin‐40 levels in diagnosing periodontal diseases.

Autor:	Babun, Fatma Köksel, Kayar, Nezahat Arzu, Hatipoğlu, Mükerrem
Předmět:	SALIVA analysis RECEIVER operating characteristic curves RESEARCH funding KRUSKAL-Wallis Test ENZYME-linked immunosorbent assay GINGIVITIS PERIODONTAL disease SEVERITY of illness index DESCRIPTIVE statistics MANN Whitney U Test CHI-squared test PROTEOLYTIC enzymes PERIODONTITIS INTERLEUKINS BIOMARKERS
Zdroj:	Oral Diseases; Nov2024, Vol. 30 Issue 8, p5315-5325, 11p
Abstrakt:	Background: The present study aimed to analyze IL‐40, IL‐1β, and MMP‐8 levels in periodontitis as well as gingivitis and periodontal health, and to explore potential correlations between these biomarkers and standard clinical parameters. Materials and methods: We collected saliva samples from 120 systemically healthy, non‐smoking individuals aged between 18 and 63 years. These individuals were divided into three groups: healthy controls [S], gingivitis [G], and stage III grade B periodontitis [P]. IL‐40, IL‐1β, and MMP‐8 levels in saliva samples were analyzed by ELISA. Results: We observed significantly elevated salivary IL‐40 levels in the G group compared to the S group (p = 0.003). We found significantly higher salivary IL‐1β levels in the P group compared to both the S and G groups (p = 0.000). Salivary MMP‐8 levels were significantly higher in the P group than in the S group (p = 0.016). Conclusion: Our study suggests that IL‐40 and IL‐1β may serve as effective salivary biomarkers for diagnosing gingivitis, while MMP‐8 and IL‐1β may be effective for distinguishing periodontitis. Based on our study's findings, it can be stated that IL‐40 may serve as a new and effective biomarker for distinguishing individuals with gingivitis from healthy ones. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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