COVID-19 clinical phenotypes in vaccinated and nonvaccinated solid organ transplant recipients: a multicenter validation study.

Autor: Infante-Domínguez, Carmen, Salto-Alejandre, Sonsoles, Álvarez-Marín, Rocío, Sabé, Nuria, Ramos-Martínez, Antonio, Moreno, Asunción, Ferreira de Moraes, Kamilla, Palacios-Baena, Zaira R., Muñoz, Patricia, Fernández-Ruiz, Mario, Blanes, Marino, Fariñas, Carmen, Vidal, Elisa, Merino de Lucas, Esperanza, Halpern, Márcia, Hernández-Gallego, Román, Bassetti, Matteo, Mularoni, Alessandra, Gutiérrez-Dalmau, Alex, Rinaldi, Matteo
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Zdroj: Scientific Reports; 12/3/2024, Vol. 14 Issue 1, p1-13, 13p
Abstrakt: Clinical phenotypes of COVID-19, associated with mortality risk, have been identified in the general population. The present study assesses their applicability in solid organ transplant recipients (SOTR) hospital-admitted by COVID-19. In a cohort of 488 SOTR, nonvaccinated (n = 394) and vaccinated (n = 94) against SARS-CoV-2, we evaluated 16 demographic, clinical, analytical, and radiological variables to identify the clinical phenotypes A, B, and C. The median age was 61.0 (51–69) years, 330 (67.6%) and 158 (32.4%) were men and women, respectively, 415 (85%) had pneumonia, and 161 (33%) had SpO2 < 95% at admission. All-cause mortality occurred in 105 (21.5%) cases. It was higher in nonvaccinated versus vaccinated SOTR (23.4% vs 13.8%, P = 0.04). Patients in the entire cohort were classified into phenotypes A (n = 149, 30.5%), B (n = 187, 38.3%), and C (n = 152, 31.1%), with mortality rates of 8.7%, 16.6%, and 40.1%, respectively, which were similar to those of nonvaccinated SOTR (9.5%, 16.7%, and 52.0%) and lower in vaccinated SOTR (4.4%, 15.8%, and 17.3%, respectively), with difference between nonvaccinated and vaccinated in the phenotype C (P < 0.001). In conclusion, COVID-19 clinical phenotypes are useful in SOTR, and all-cause mortality decreases in vaccinated patients. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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