| Autor: |
Yakovleva, O. V., Skripnikova, V. V., Yakovlev, A. V., Sitdikova, G. F. |
| Předmět: |
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| Zdroj: |
Neuroscience & Behavioral Physiology; Oct2024, Vol. 54 Issue 8, p1277-1288, 12p |
| Abstrakt: |
Unfavorable conditions affecting mothers during pregnancy not only disrupt the development of the offspring, but can also affect subsequent generations. Epigenetic regulation of transcription is among the factors able to mediate hereditary metabolic diseases. Epigenetic modifications of the genome are observed in conditions of elevated blood homocysteine concentrations, which can be accompanied by changes in the fetal brain development program and cognitive impairment. The aim of the present work was to analyze the sensorimotor development, behavioral reactions, and cognitive functions of the offspring of rats with hyperhomocysteinemia in the second generation (HHcyF2). These studies demonstrated delays in the formation of unconditioned reflexes and physical parameters in HHcyF2 rats. Investigations in the open field test showed that these animals displayed high anxiety and decreased exploratory and motor activity, while motor coordination in the rotarod test was not impaired despite a decrease in limb muscle strength in a grip strength test. Learning and long-term memory in the Morris water maze test were impaired in HHcyF2 rats. Biochemical analysis revealed an imbalance in the functioning of antioxidant systems due to decreases in the activity of glutathione peroxidase and the enzymes of hydrogen sulfide synthesis. These studies suggest that high homocysteine levels during pregnancy lead to epigenetic changes in the genome which affect metabolism in the offspring and are transmitted to subsequent generations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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