| Abstrakt: |
Objective. To analyze patients with long-term survival in a group of patients with glioblastoma after use of photodynamic therapy in the structure of their complex treatment with the purpose of assessing the influences of various factors on survival time. Materials and methods. A single-center, retrospective, categorical study was run to analyze the long-term results of treatment in 63 patients with glioblastoma whose complex treatment regimes included photodynamic therapy. The following factors were analyzed: clinical factors (age, sex, number of cases, preoperative Karnofsky index, tumor location and size, radicality of surgery), histological factors (nuclear polymorphism, mitoses, vascular proliferation, necrosis), immunohistochemical factors (Ki-67 index, p53), molecular genetic factors (expression of VEGF, MGMT, IDH, and CD34), and the volume of radiation and chemotherapy. Results. The data obtained here showed that overall group of patients displayed direct correlations between survival duration and MGMT status, IDH status, number of chemotherapy courses, age, and radicality of first surgery. Conclusions. Clinical features such as age at diagnosis and the extent of surgical resection and the volume of chemotherapy were found to have prognostic significance in assessing impacts on survival time. IDH mutations and MGMT promoter methylation were the most important molecular factors determining the long-term survival of patients. [ABSTRACT FROM AUTHOR] |
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