| Autor: |
Knörnschild, Franz L., Liebig, Sven, Kießling, Peggy, Prpic, Monika, Kim, Tehyung, Keller, Ulrich, Kappert, Kai, Schwartz, Stefan, Jahic, Amir |
| Předmět: |
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| Zdroj: |
Clinical Chemistry & Laboratory Medicine; Jan2025, Vol. 63 Issue 1, pe11-e15, 5p |
| Abstrakt: |
The document discusses simplified preanalytical laboratory procedures for therapeutic drug monitoring (TDM) in patients treated with high-dose methotrexate (HD-MTX) and glucarpidase. High-dose methotrexate therapy is used in various malignancies, but can occasionally cause acute crystal nephropathy. Glucarpidase is an enzyme that rapidly cleaves methotrexate and its metabolites, and therapeutic drug monitoring is essential for patients treated with glucarpidase. The study found that preanalytical blood sample processing without acidification is sufficient for TDM, but storage conditions can impact the quantification of methotrexate and its metabolites, highlighting the importance of proper sample storage for clinical decision-making. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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