Design of a New Nano-carrier for the Anticancer Drug Topotecan Based on Carbon Nanotube and Investigating the Mechanism of Its Passage Through Cell Membranes.

Autor: Rahmanifar, Elham, Saheb, Vahid, Yoosefian, Mehdi
Zdroj: BioNanoScience; Mar2025, Vol. 15 Issue 1, p1-10, 10p
Abstrakt: Drug delivery plays a pivotal and essential role in modern medicine. This field encompasses a wide range of strategies and technologies designed to facilitate the safe transportation of therapeutic agents within living organisms. These systems serve a fundamental role in addressing various challenges in drug delivery, including reducing side effects and enhancing drug delivery efficiency. In this context, nanostructures, especially carbon nanotubes, stand out as innovative platforms with unique properties that enable precise drug delivery. This study focuses on the encapsulation of the potent anticancer drug topotecan (TPT) within carbon nanotubes. The objective of this research is to enhance drug efficacy while minimizing off-target effects. For a more precise evaluation of this process, we utilize a DPPC membrane model and molecular dynamics as research tools. These tools allow us to investigate the passage of this drug delivery system through cellular membranes, providing insights that contribute to the precise and targeted delivery of drugs. In conclusion, the findings of this study demonstrate the high efficacy of carbon nanotubes as a drug delivery system for the anticancer drug topotecan and their significant potential for successful penetration into the cellular membrane. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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