Mild boroxazolidone formation and dissociation: application toward target identification of bioactive molecules.

Autor: Tabei, Toya, Nakagawa-Goto, Kyoko, Saito, Yohei
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Zdroj: Chemical Communications; 12/14/2024, Vol. 60 Issue 96, p14252-14255, 4p
Abstrakt: We successfully found that boroxazolidone can dissociate under aqueous conditions, which were applicable to a solution containing proteins. The immobilization of a newly synthesized diarylborinic acid on beads enabled the capture and release of target proteins of bioactive compounds through boroxazolidone formation and dissociation. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index