| Autor: |
Juárez-Cedillo, Teresa, Martínez-Rodríguez, Nancy, Juárez-Cedillo, Enrique, Ramirez, Alfredo, Suerna-Hernández, Alan |
| Předmět: |
|
| Zdroj: |
Genes; Nov2024, Vol. 15 Issue 11, p1395, 11p |
| Abstrakt: |
Background: Dementia causes the loss of functional independence, resulting in a decrease in the quality of life of those who suffer from it. Aims: This study aimed to investigate the interactions influencing susceptibility to the development of dementia through multifactor dimensionality reduction (MDR). Methods: the study population was made up of 221 cases and 534 controls. We performed an MDR analysis as well as a bioinformatic analysis to identify interactions between the genes GSTO1_rs4925, AGER_rs2070600, and ESR1_rs3844508 associated with susceptibility to dementia. Results: We observed associations between the polymorphism of GSTO1 and risk of dementia for the site rs4925 with the recessive model (OR = 1.720, 95% CI = 1.166–2.537 p = 0.006). Similarly, the site AGER rs2070600 showed risk of dementia with an additive model of inheritance (OR = 7.278, 95% CI = 3.140–16.868; p < 0.001). Furthermore, we identified the best risk model with a high precision of 79.6% that, when combined with three environmental risk factors, did not give an OR = 26.662 95%CI (16.164–43.979) with p < 0.001. Conclusions: The MDR and bioinformatics results provide new information on the molecular pathogenesis of dementia, allowing identification of possible diagnostic markers and new therapeutic targets. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
