| Autor: |
Sorrentino, Francesco Saverio, Culiersi, Carola, Florido, Antonio, De Nadai, Katia, Adamo, Ginevra Giovanna, Nasini, Francesco, Vivarelli, Chiara, Mura, Marco, Parmeggiani, Francesco |
| Předmět: |
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| Zdroj: |
Genes; Nov2024, Vol. 15 Issue 11, p1356, 15p |
| Abstrakt: |
Background/Objectives: Although it comprises only 5% of all melanomas, uveal melanoma (UM) is the most commonly observed primary intraocular cancer. Methods: Poor patient survival persists in spite of innovative systemic therapies. In fact, approximately fifty percent of UM patients develop metastases from micro-metastases that remain undetected at the exact time of diagnosis. Results: The molecular understanding of UM is significantly enhanced by the recent identification of several mutations that are responsible for the metastasis, growth, and survival of UM. The crucial point is a more accurate genetic analysis for patient follow-up and metastatic risk prediction. Conclusions: This review provides a brief summary of the molecular features of UM that are recently discovered, as well as cytogenetic markers and biochemical pathways that are associated with the development of UM metastases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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