| Autor: |
Hsu, Chih‐Wei, Wu, Chun‐Fu, Lee, Yung‐Chi, Yoo, Woo‐Jin |
| Předmět: |
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| Zdroj: |
Advanced Synthesis & Catalysis; Nov2024, Vol. 366 Issue 22, p4747-4754, 8p |
| Abstrakt: |
The replacement of benzene rings with saturated bioisosteric counterparts is a key priority in drug discovery programs, and disubstituted bicyclo[2.1.1]hexanes have been recognized as flexible molecular scaffolds that could act as ortho‐substituted benzene bioisosteres. In this study, we outline the synthesis of a wide range of 2‐substituted bicyclo[2.1.1]hexan‐1‐ols, which have the potential to emulate ortho‐phenolic derivatives, via SmI2‐mediated reductive cyclization reactions. The synthetic utility of this methodology was exemplified by the preparation of several saturated analogs of pharmaceutically relevant compounds. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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